Article
Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients.
Carcinogenesis - 1 Jan 2006
Khan Sikandar G, Oh Kyu-Seon, Shahlavi Tala, Ueda Takahiro, Busch David B, Inui Hiroki, Emmert Steffen, Imoto Kyoko, Muniz-Medina Vanessa, Baker Carl C, DiGiovanna John J, Schmidt Deborah, Khadavi Arash, Metin Ahmet, Gozukara Engin, Slor Hanoch, Sarasin Alain, Kraemer Kenneth H
Abstract excerpt
Xeroderma pigmentosum group C (XP-C) is a rare autosomal recessive disorder. Patients with two mutant alleles of the XPC DNA repair gene have sun sensitivity and a 1000-fold increase in skin cancers. Clinically normal parents of XP-C patients have one mutant allele and one normal allele. As a step toward evaluating cancer risk in these XPC heterozygotes we characterized cells from 16 XP families. We identified 15...
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