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Article

Glia instruct developmental neuronal remodeling through TGF-β signaling.

Nature neuroscience - 19 Jun 2011

Awasaki Takeshi, Huang Yaling, O'Connor Michael B, Lee Tzumin

Abstract excerpt

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

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Identifiers

PMID: 21685919
DOI: 10.1038/nn.2833
PMCID: PMC3337551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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