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Article

Regulation of neuroblast proliferation by surface glia in the Drosophila larval brain.

Scientific reports - 27 Feb 2018

Kanai Makoto I, Kim Myung-Jun, Akiyama Takuya, Takemura Masahiko, Wharton Kristi, O'Connor Michael B, Nakato Hiroshi

Abstract excerpt

Despite the importance of precisely regulating stem cell division, the molecular basis for this control is still elusive. Here, we show that surface glia in the developing Drosophila brain play essential roles in regulating the proliferation of neural stem cells, neuroblasts (NBs). We found that two classes of extracellular factors, Dally-like (Dlp), a heparan sulfate proteoglycan, and Glass bottom boat (Gbb), a...

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Identifiers

PMID: 29487331
DOI: 10.1038/s41598-018-22028-y
PMCID: PMC5829083

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