Article
Glia relay differentiation cues to coordinate neuronal development in Drosophila.
Science (New York, N.Y.) - 1 Sept 2017
Fernandes Vilaiwan M, Chen Zhenqing, Rossi Anthony M, Zipfel Jaqueline, Desplan Claude
Abstract excerpt
Neuronal birth and specification must be coordinated across the developing brain to generate the neurons that constitute neural circuits. We used the Drosophila visual system to investigate how development is coordinated to establish retinotopy, a feature of all visual systems. Photoreceptors achieve retinotopy by inducing their target field in the optic lobe, the lamina neurons, with a secreted differentiation...
Topics
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- ErbB Receptors
- Insulin
- Membrane Proteins
- Mutation
- Neurogenesis
- Neuroglia
- Optic Lobe, Nonmammalian
- Photoreceptor Cells, Invertebrate
- Receptors, Invertebrate Peptide
- Serine Endopeptidases
- Signal Transduction