Article
glial cells missing: a binary switch between neuronal and glial determination in Drosophila.
Cell - 22 Sept 1995
Hosoya T, Takizawa K, Nitta K, Hotta Y
Abstract excerpt
In the Drosophila CNS, both neurons and glial are derived from neuroblasts. We have identified a gene, glial cells missing (gcm), that encodes a novel nuclear protein expressed transiently in early glial cells. Its mutation causes presumptive glial cells to differentiate into neurons, whereas its ectopic expression forces virtually all CNS cells to become glial cells. Thus, gcm functions as a binary switch that...
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