Article
Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Shore S K, Bogart S L, Reddy E P
Abstract excerpt
Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, in Hardy-Zuckerman 2 feline sarcoma virus, and during the chromosomal translocations that generate BCR-ABL gene fusion products. To study the molecular mechanism involved in the c-abl activation, we have created a series of modifications in murine c-abl and assayed these constructs for oncogenic activity using the NIH 3T3 cell...
Topics
- Abelson murine leukemia virus
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Deletion
- Gene Expression Regulation
- Genetic Vectors
- Leukemia Virus, Murine
- Mice
- Mutation
- Plasmids