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Article

Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Shore S K, Bogart S L, Reddy E P

Abstract excerpt

Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, in Hardy-Zuckerman 2 feline sarcoma virus, and during the chromosomal translocations that generate BCR-ABL gene fusion products. To study the molecular mechanism involved in the c-abl activation, we have created a series of modifications in murine c-abl and assayed these constructs for oncogenic activity using the NIH 3T3 cell...

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Identifiers

PMID: 2168550
DOI: 10.1073/pnas.87.17.6502
PMCID: PMC54564

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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