Article
Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors.
Toxicology letters - 1 Apr 1993
Storm S M, Rapp U R
Abstract excerpt
We demonstrate here consistent point mutations of the c-raf-1 proto-oncogene, within a small region of the kinase domain, in a mouse model for chemical tumor induction. This is the first demonstration of point mutated raf genes in vivo, and the first isolation of activating in vivo point mutation...
Topics
- Animals
- Butylated Hydroxytoluene
- Crosses, Genetic
- DNA Mutational Analysis
- Ethylnitrosourea
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Lung Neoplasms
- Mice
- Mice, Inbred AKR
- Multigene Family
- Mutation
- Neoplasms
- Neoplasms, Experimental
- Oncogenes
- Point Mutation
- Proto-Oncogene Mas