Article
An activating amino acid substitution in the c-abl oncogene protein fails to produce a local conformational change.
Journal of protein chemistry - 1 Aug 1991
Brandt-Rauf P W, Bomzer G, Belford D, Pincus M R
Abstract excerpt
The bcr-abl chimeric gene of Philadelphia chromosome positive chronic myelogenous leukemias is only weakly transforming. This transformation activity is greatly enhanced by a Lys-for-Glu substitution at position 832 in the c-abl gene, as occurs in the highly transforming v-abl genes. It has been...
Topics
- Amino Acid Sequence
- Cell Transformation, Neoplastic
- Genes, abl
- Glutamates
- Humans
- Lysine
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oncogene Proteins
- Philadelphia Chromosome
- Protein Conformation