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Article

Bone marrow-transforming activity of linker insertion mutants of Abelson murine leukemia virus.

Oncogene - 1 Nov 1992

Hevezi P, Alin K, Rees-Jones R, Goff S P

Abstract excerpt

Two sets of mutants of the Abelson murine leukemia virus, generated by linker insertion mutagenesis of a cloned proviral DNA, were tested for their ability to transform bone marrow cultures in vitro. All the viruses retained an intact tyrosine kinase domain and were competent for transformation of NIH3T3 fibroblasts in culture. One series contained 12-bp linker insertions in the regions flanking the kinase...

Topics

3T3 Cells
Abelson murine leukemia virus
Animals
B-Lymphocytes
Bone Marrow
Cell Transformation, Neoplastic
Cells, Cultured
DNA, Viral
Hematopoietic Stem Cells
Mice
Mutagenesis, Insertional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins v-abl

Structure-Activity Relationship

Source

Identifiers

PMID: 1437154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1437154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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