Article
Oncogenic activation of c-ABL by mutation within its last exon.
Molecular and cellular biology - 1 Aug 1993
Goga A, McLaughlin J, Pendergast A M, Parmar K, Muller A, Rosenberg N, Witte O N
Abstract excerpt
The c-ABL proto-oncogene is a predominantly nuclear localized tyrosine kinase. A random mutagenesis scheme was used to isolate c-ABL mutants whose expression produced a transformed phenotype in rodent fibroblast cells. An in-frame deletion within the central region of the last exon was identified...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Cell Compartmentation
- Cell Transformation, Neoplastic
- Cytoplasm
- DNA Mutational Analysis
- DNA-Binding Proteins
- Exons
- Genes, abl
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Protein Kinases
- Proto-Oncogene Proteins c-abl
- Recombinant Proteins
- Sequence Deletion