Article
Type 2 deiodinase and host responses of sepsis and acute lung injury.
American journal of respiratory cell and molecular biology - 1 Dec 2011
Ma Shwu-Fan, Xie Lishi, Pino-Yanes Maria, Sammani Saad, Wade Michael S, Letsiou Eleftheria, Siegler Jessica, Wang Ting, Infusino Giovanni, Kittles Rick A, Flores Carlos, Zhou Tong, Prabhakar Bellur S, Moreno-Vinasco Liliana, Villar Jesus, Jacobson Jeffrey R, Dudek Steven M, Garcia Joe G N
Abstract excerpt
The role of thyroid hormone metabolism in clinical outcomes of the critically ill remains unclear. Using preclinical models of acute lung injury (ALI), we assessed the gene and protein expression of type 2 deiodinase (DIO2), a key driver for synthesis of biologically active triiodothyronine, and addressed potential association of DIO2 genetic variants with ALI in a multiethnic cohort. DIO2 gene and protein...
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