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Article

From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2009

Friedman David J, Künzli Beat M, A-Rahim Yousif I, Sevigny Jean, Berberat Pascal O, Enjyoji Keiichi, Csizmadia Eva, Friess Helmut, Robson Simon C

Abstract excerpt

CD39/ENTPD1 hydrolyzes proinflammatory nucleotides to generate adenosine. As purinergic mediators have been implicated in intestinal inflammation, we hypothesized that CD39 might protect against inflammatory bowel disease. We studied these possibilities in a mouse model of colitis using mice with global CD39 deletion. We then tested whether human genetic polymorphisms in the CD39 gene might influence...

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Source

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Identifiers

PMID: 19805374
DOI: 10.1073/pnas.0902869106
PMCID: PMC2757811

Genes

ENTPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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