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Article

Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P.

RNA (New York, N.Y.) - 1 Jun 2003

Zahler Nathan H, Christian Eric L, Harris Michael E

Abstract excerpt

The bacterial tRNA processing enzyme ribonuclease P (RNase P) is a ribonucleoprotein composed of a approximately 400 nucleotide RNA and a smaller protein subunit. It has been established that RNase P RNA contacts the mature tRNA portion of pre-tRNA substrates, whereas RNase P protein interacts with the 5' leader sequence. However, specific interactions with substrate nucleotides flanking the cleavage site have...

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Identifiers

PMID: 12756331
DOI: 10.1261/rna.5220703
PMCID: PMC1370440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P.PMID 12756331Read ↗

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