Article
Detection of single nucleotide polymorphisms by a gold nanowire-on-film SERS sensor coupled with S1 nuclease treatment.
Chemistry (Weinheim an der Bergstrasse, Germany) - 25 Jul 2011
Yoo Seung Min, Kang Taejoon, Kim Bongsoo, Lee Sang Yup
Abstract excerpt
Single nucleotide polymorphisms (SNPs) can serve as important biomarkers for genetic diseases, for which accurate detection of SNPs is essential for early diagnosis. We have developed a novel SNP sensor by combining a Au nanowire-on-film surface-enhanced Raman scattering (SERS) platform with S1 nuclease reaction. The combined sensor system provides reproducible SERS signals only in the presence of perfectly...
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