Hydroxylamine-amplified gold nanoparticles for the naked eye and chemiluminescent detection of sequence-specific DNA with notable potential for single-nucleotide polymorphism discrimination.

Abstract excerpt

Herein, we report a hydroxylamine-amplified gold nanoparticle-based assay with naked eye and chemiluminescent (CL) detection of sequence-specific DNA. For the naked eye detection assay, the signal can be observed by naked eye directly, which provides a general way for other biological assays. In contrast, the CL detection method can improve the detection limit by two orders of magnitude as compared to the naked...

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