Article
Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.
Antimicrobial agents and chemotherapy - 1 Jul 2013
Spickler Catherine, Lippens Julie, Laberge Marie-Kristine, Desmeules Sophie, Bellavance Édith, Garneau Michel, Guo Tim, Hucke Oliver, Leyssen Pieter, Neyts Johan, Vaillancourt Fréderic H, Décor Anne, O'Meara Jeff, Franti Michael, Gauthier Annick
Abstract excerpt
Human rhinovirus (HRV) is the predominant cause of the common cold, but more importantly, infection may have serious repercussions in asthmatics and chronic obstructive pulmonary disorder (COPD) patients. A cell-based antiviral screen against HRV was performed with a subset of our proprietary compound collection, and an aminothiazole series with pan-HRV species and enteroviral activity was identified. The series...
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