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Article

In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.

Antimicrobial agents and chemotherapy - 1 Dec 2007

Binford S L, Weady P T, Maldonado F, Brothers M A, Matthews D A, Patick A K

Abstract excerpt

Rupintrivir (formerly AG7088) is an irreversible inhibitor of the human rhinovirus (HRV) 3C protease that has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction with a strictly conserved subset of amino acids in the 3C protease. The potential for resistance was studied following in vitro serial passage of HRV serotypes 14, 2, 39, and Hanks in the presence of...

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Identifiers

PMID: 17908951
DOI: 10.1128/AAC.00905-07
PMCID: PMC2167992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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