Article
DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Sept 1995
Yonezawa M, Takahata M, Matsubara N, Watanabe Y, Narita H
Abstract excerpt
The mutations in the quinolone resistance-determining region of the gyrA gene from clinical isolates of Pseudomonas aeruginosa were determined by DNA sequencing. The strains were isolated in 1989 and 1993. No mutations were detected in the clinical isolates in 1989, while five types of mutations...
Topics
- 4-Quinolones
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- Cloning, Molecular
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Escherichia coli
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Pseudomonas Infections
- Pseudomonas aeruginosa