Article
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.
Antimicrobial agents and chemotherapy - 1 Feb 1995
Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y
Abstract excerpt
Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- DNA Gyrase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Molecular Sequence Data
- Mutation
- Neisseria gonorrhoeae