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Article

Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2011

Kramann Rafael, Couson Simone K, Neuss Sabine, Kunter Uta, Bovi Manfred, Bornemann Jörg, Knüchel Ruth, Jahnen-Dechent Willi, Floege Jürgen, Schneider Rebekka K

Abstract excerpt

OBJECTIVE: Medial artery calcification in patients with chronic kidney disease proceeds through intramembranous ossification resulting from osteoblast-induced calcification of the collagen extracellular matrix. The current study is based on the hypothesis that mesenchymal stem cells (MSC) constitute critical cells for procalcific extracellular matrix remodeling in patients with chronic kidney disease. METHODS AND...

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Identifiers

PMID: 21680902
DOI: 10.1161/ATVBAHA.111.228601

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MSC

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