Article
Uremic serum exposure leads to differential phenotypic switch in porcine arterial and venous smooth muscle cells.
American journal of physiology. Renal physiology - 1 Dec 2025
Su Huanjuan, Uriyanghai Unimunkh, Wai Christine, Arteaga Eyla C, Wan Haibao, Adam Klaus-Peter, Sudarsanam Vinay A, Haddad Samuel O'Brien, Yang Anthony, Li Lianxia, Bahnson Edward M, Poulton John S, Roy-Chaudhury Prabir, Xi Gang
Abstract excerpt
Many patients with end-stage kidney disease (ESKD) frequently suffer from both aggressive vascular access stenosis in the venous segment of arteriovenous fistula or arteriovenous graft, and widespread cardiovascular disease (CVD) or peripheral arterial disease (PAD). Despite the magnitude of these clinical problems, the pathogenic role of the uremic state in both of these conditions remains unclear. To...
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