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Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2010

Neven Ellen, Persy Veerle, Dauwe Simonne, De Schutter Tineke, De Broe Marc E, D'Haese Patrick C

Abstract excerpt

OBJECTIVE: To investigate cell biological changes in calcified aortas of rats that experienced chronic renal failure. METHODS AND RESULTS: Vascular smooth muscle cells have the potential to transdifferentiate to either chondrocytes or osteoblasts, depending on the molecular pathways that are stimulated. Uremia-related medial calcification was induced by feeding rats an adenine low-protein diet for 4 weeks. Aortic...

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PMID: 20522801
DOI: 10.1161/ATVBAHA.110.204834

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