Article
The role of platelet-derived growth factor in uremic vascular calcification.
Kidney international - 1 Sept 2026
Öztürk Burcu Yesilyurt, Zhang Li, von Stillfried Saskia, Klinkhammer Barbara Mara, Möllmann Julia, Nguyen Lisa, Droste Patrick, Buhl Eva Miriam, Hohl Mathias, Noels Heidi, Jankowski Vera, Jankowski Joachim, Goettsch Claudia, Marx Nikolaus, Olson Lorin E, Rosenkranz Stephan, Floege Jürgen, Wong Dickson W L, Boor Peter
Abstract excerpt
INTRODUCTION: Vascular calcification is common in chronic kidney disease (CKD), contributing to increased cardiovascular morbidity and mortality. A proposed mechanism for driving vascular calcification is a phenotypic switch of vascular smooth muscle cells (VSMCs). The platelet derived growth factors (PDGFs) and their receptors (PDGFRs), particularly PDGFR-β, were shown to modulate the VSMC phenotype. However,...
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