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Article

Harmful effects of the azathioprine metabolite 6-mercaptopurine in vascular cells: induction of mineralization.

PloS one - 1 Jan 2014

Prüfer Jasmin, Schuchardt Mirjam, Tölle Markus, Prüfer Nicole, Höhne Matthias, Zidek Walter, van der Giet Markus

Abstract excerpt

Vascular mineralization contributes to the high cardiovascular morbidity and mortality in patients who suffer from chronic kidney disease and in individuals who have undergone solid organ transplantation. The immunosuppressive regimen used to treat these patients appears to have an impact on vascular alterations. The effect of 6-mercaptopurine (6-MP) on vascular calcification has not yet been determined. This...

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Identifiers

PMID: 25029363
DOI: 10.1371/journal.pone.0101709
PMCID: PMC4100760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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