Article
c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice.
Molecular biology of the cell - 1 Aug 2011
Olaku Vivienne, Matzke Alexandra, Mitchell Claudia, Hasenauer Susanne, Sakkaravarthi Arul, Pace Giuseppina, Ponta Helmut, Orian-Rousseau Véronique
Abstract excerpt
CD44 isoforms act as coreceptors for the receptor tyrosine kinases c-Met and VEGFR-2. However, Cd44 knockout mice do not show overt phenotypes, in contrast to Met and Vegfr-2 knockout mice. We hypothesized that CD44 is being compensated for by another factor in Cd44 null mice. Using RNAi technology and blocking experiments with antibodies, peptides, and purified ectodomains, as well as overexpression studies, we...
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