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Article

Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo.

Journal of virology - 15 Feb 2017

Ding Qiang, von Schaewen Markus, Hrebikova Gabriela, Heller Brigitte, Sandmann Lisa, Plaas Mario, Ploss Alexander

Abstract excerpt

Hepatitis C virus (HCV) causes chronic infections in at least 150 million individuals worldwide. HCV has a narrow host range and robustly infects only humans and chimpanzees. The underlying mechanisms for this narrow host range are incompletely understood. At the level of entry, differences in the amino acid sequences between the human and mouse orthologues of two essential host factors, the tetraspanin CD81 and...

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PMID: 27928007
DOI: 10.1128/JVI.01799-16
PMCID: PMC5286898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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