Preliminary study on the DNA-binding properties of phage ΦC31 integrase.

doi:10.1016/j.gene.2011.05.020

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Article

Preliminary study on the DNA-binding properties of phage ΦC31 integrase.

Gene - 15 Sept 2011

Li Zhihui, Fang Yuxiang, Wang Rencheng, Xue Jinglun, Chen Jinzhong

Abstract excerpt

ΦC31 integrase is a member of the large serine subfamily and is required for the recombination of the phage genome into the host chromosome, either to establish or exit from the lysogenic state. This enzyme can also mediate site-specific integration in mammalian cells in a cofactor-independent manner and has been considered as a potentially powerful tool for gene therapy. It has previously been reported that DAXX...

Topics

Amino Acid Sequence
Attachment Sites, Microbiological
Bacteriophages
DNA-Binding Proteins
Integrases
Molecular Sequence Data
Mutation
Protein Structure, Secondary
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 21679753
DOI: 10.1016/j.gene.2011.05.020

Genes

DAXX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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