Article
Identifying determinants of recombination specificity: construction and characterization of chimeric bacteriophage integrases.
Journal of molecular biology - 15 Sept 1995
Yagil E, Dorgai L, Weisberg R A
Abstract excerpt
Bacteriophage integrases are members of a family of structurally related enzymes that promote recombination between DNA molecules that carry specific sites. Phages lambda and HK022 encode closely related integrases that recognize different sets of sequences within the core regions of their respective attachment sites. To locate the amino acid residues that determine this difference in specificity, we isolated...
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