Article
Tumoricidal effector mechanisms of murine BCG-activated macrophages: role of TNF in conjugation-dependent and conjugation-independent pathways.
Journal of leukocyte biology - 1 Sept 1990
Klostergaard J, Stoltje P A, Kull F C
Abstract excerpt
The roles of secreted and membrane-associated TNFs were investigated in activated macrophage cytolysis of L929, EMT-6, and P815 targets. While all three targets were susceptible to cytolysis in coculture, an anti-TNF antiserum blocked lysis of L929 and EMT-6 but not of the P815 targets. Of the th...
Topics
- Animals
- Conjugation, Genetic
- Cytotoxins
- Fibroblasts
- Immune Sera
- Interferon Type I
- Macrophage Activation
- Macrophages
- Male
- Mice
- Mycobacterium bovis
- Phenotype
- Receptors, Cell Surface
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha