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Article

Loss of bacillus Calmette-Guérin viability adversely affects the direct response of urothelial carcinoma cells to bacillus Calmette-Guérin exposure.

The Journal of urology - 1 Mar 2014

Shah Gopitkumar, Zhang Guangjian, Chen Fanghong, Cao YanLi, Kalyanaraman Balaraman, See William

Abstract excerpt

PURPOSE: The attenuated mycobacterium bacillus Calmette-Guérin is widely used as intravesical immunotherapy for nonmuscle invasive urothelial carcinoma. Previous studies demonstrated that in the laboratory and clinical settings bacillus Calmette-Guérin viability is a variable that correlates with antitumor efficacy. We evaluated how loss of viability impacted a number of molecular and phenotypic intermediate end...

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Identifiers

PMID: 24035882
DOI: 10.1016/j.juro.2013.09.012
PMCID: PMC5798236

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