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Article

BMI1'S maintenance of the proliferative capacity of laryngeal cancer stem cells

6 Dec 2010

Abstract excerpt

BACKGROUND: In laryngeal squamous cell carcinoma (SCC), CD133+ cells were found to display cancer stem cell (CSC) characteristics. BMI1 is an oncogene that plays key roles in proliferation in CSCs. However, no published reports have examined the role of BMI1 in laryngeal CSCs. METHODS: Immunofluorescence staining confirmed the coexpression of BMI1 and CD133. After sorting, real-time polymerase chain reaction...

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PMID: 21755556
DOI: 10.1002/hed.21576

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