Article
A pilot study of bacterial genes with disrupted ORFs reveals a surprising profusion of protein sequence recoding mediated by ribosomal frameshifting and transcriptional realignment.
Molecular biology and evolution - 1 Nov 2011
Sharma Virag, Firth Andrew E, Antonov Ivan, Fayet Olivier, Atkins John F, Borodovsky Mark, Baranov Pavel V
Abstract excerpt
Bacterial genome annotations contain a number of coding sequences (CDSs) that, in spite of reading frame disruptions, encode a single continuous polypeptide. Such disruptions have different origins: sequencing errors, frameshift, or stop codon mutations, as well as instances of utilization of nontriplet decoding. We have extracted over 1,000 CDSs with annotated disruptions and found that about 75% of them can be...
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