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Article

Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC).

BMC genomics - 24 Feb 2016

Neuhaus Klaus, Landstorfer Richard, Fellner Lea, Simon Svenja, Schafferhans Andrea, Goldberg Tatyana, Marx Harald, Ozoline Olga N, Rost Burkhard, Kuster Bernhard, Keim Daniel A, Scherer Siegfried

Abstract excerpt

BACKGROUND: Genomes of E. coli, including that of the human pathogen Escherichia coli O157:H7 (EHEC) EDL933, still harbor undetected protein-coding genes which, apparently, have escaped annotation due to their small size and non-essential function. To find such genes, global gene expression of EHEC EDL933 was examined, using strand-specific RNAseq (transcriptome), ribosomal footprinting (translatome) and mass...

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Identifiers

PMID: 26911138
DOI: 10.1186/s12864-016-2456-1
PMCID: PMC4765031

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Source receipt: pubmed, retrieved 7 Sept 2026.

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