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Article

HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia

29 Sept 2014

Abstract excerpt

Self-renewal of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs) has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia-inducible factors (HIFs). Whether HIF-1α can be used as a therapeutic target in the treatment of...

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PMID: 25267197
DOI: 10.1182/blood-2014-04-567065

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