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Article

Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors.

Frontiers in immunology - 1 Jan 2019

Pang Yuan-Ping, Casal Moura Marta, Thompson Gwen E, Nelson Darlene R, Hummel Amber M, Jenne Dieter E, Emerling Daniel, Volkmuth Wayne, Robinson William H, Specks Ulrich

Abstract excerpt

Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can be interrupted. Here we report that iHm5-Val103, a triple mutant of iPR3-Val103, bound a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31708920
DOI: 10.3389/fimmu.2019.02467
PMCID: PMC6823208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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