Article
The glycosylation of the extracellular loop of β2 subunits diversifies functional phenotypes of BK Channels.
Channels (Austin, Tex.) - 4 Mar 2017
Huang Zhi-Gang, Liu Hao-Wen, Yan Zhen-Zhen, Wang Sheng, Wang Lu-Yang, Ding Jiu-Ping
Abstract excerpt
Large-conductance Ca2+- and voltage-activated potassium (MaxiK or BK) channels are composed of a pore-forming α subunit (Slo) and 4 types of auxiliary β subunits or just a pore-forming α subunit. Although multiple N-linked glycosylation sites in the extracellular loop of β subunits have been identified, very little is known about how glycosylation influences the structure and function of BK channels. Using a...
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