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Article

Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products.

Journal of virology - 1 Sept 1990

Zhu X X, Chen J X, Young C S, Silverstein S

Abstract excerpt

We have previously shown that adenovirus recombinants expressing functional ICP0 reactivate latent herpes simplex virus type 2 (HSV-2) in an in vitro latency system. This study demonstrated that ICP0, independent of other HSV gene products, is sufficient to reactivate latent HSV-2 in this in vitro system. To assess the effects of defined mutations in the sequence encoding ICP0 (IE-0) on reactivation, seven...

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Identifiers

PMID: 2166826
DOI: 10.1128/JVI.64.9.4489-4498.1990
PMCID: PMC247919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products.PMID 2166826Read ↗

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A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiency.Semantic proximity Read ↗

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The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta.Semantic proximity Read ↗

ICP0, a regulator of herpes simplex virus during lytic and latent infectionSemantic proximity Read ↗

Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo.Semantic proximity Read ↗

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.Semantic proximity Read ↗

Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p.Semantic proximity Read ↗

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Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.Semantic proximity Read ↗

Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.Semantic proximity Read ↗

Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

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