Article
Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products.
Journal of virology - 1 Sept 1990
Zhu X X, Chen J X, Young C S, Silverstein S
Abstract excerpt
We have previously shown that adenovirus recombinants expressing functional ICP0 reactivate latent herpes simplex virus type 2 (HSV-2) in an in vitro latency system. This study demonstrated that ICP0, independent of other HSV gene products, is sufficient to reactivate latent HSV-2 in this in vitr...
Topics
- Adenoviruses, Human
- Animals
- Chloramphenicol O-Acetyltransferase
- DNA, Viral
- Genes, Viral
- HeLa Cells
- Humans
- Immediate-Early Proteins
- Kinetics
- Mutation
- Recombination, Genetic
- Simplexvirus
- Thymidine Kinase
- Transcriptional Activation
- Transfection
- Ubiquitin-Protein Ligases
- Vero Cells
- Viral Proteins