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Article

A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiency.

Journal of virology - 1 Oct 1991

Natarajan R, Deshmane S, Valyi-Nagy T, Everett R, Fraser N W

Abstract excerpt

Previous evidence suggests that the latency-associated transcript (LAT) gene of herpes simplex virus type 1 appears to have a role during reactivation of latent virus because viruses which are null mutants in this gene reactivate slowly or less efficiently than wild-type viruses. Mapping studies have shown that the LAT gene covers a region of about 8.5 kb that overlaps the ICP0 gene in the repeat long region of...

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Identifiers

PMID: 1654452
DOI: 10.1128/JVI.65.10.5569-5573.1991
PMCID: PMC249065

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiency.PMID 1654452Read ↗

A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics.Semantic proximity Read ↗

An HSV-1 mutant lacking the LAT TATA element reactivates normally in explant cocultivation.Semantic proximity Read ↗

Herpes Simplex Virus 2 Latency-Associated Transcript (LAT) Region Mutations Do Not Identify a Role for LAT-Associated MicroRNAs in Viral Reactivation in Guinea Pig Genital Models.Semantic proximity Read ↗

Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo.Semantic proximity Read ↗

Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.Semantic proximity Read ↗

Reactivation of expression from quiescent herpes simplex virus type 1 genomes in the absence of immediate-early protein ICP0.Semantic proximity Read ↗

A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivationSemantic proximity Read ↗

A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation.Semantic proximity Read ↗

A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.Semantic proximity Read ↗

Herpes simplex virus latency-associated transcript is a stable intron.Semantic proximity Read ↗

Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products.Semantic proximity Read ↗

Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs.Semantic proximity Read ↗

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