Article
A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiency.
Journal of virology - 1 Oct 1991
Natarajan R, Deshmane S, Valyi-Nagy T, Everett R, Fraser N W
Abstract excerpt
Previous evidence suggests that the latency-associated transcript (LAT) gene of herpes simplex virus type 1 appears to have a role during reactivation of latent virus because viruses which are null mutants in this gene reactivate slowly or less efficiently than wild-type viruses. Mapping studies...
Topics
- Animals
- Blotting, Northern
- Cell Line
- Chromosome Deletion
- DNA, Viral
- Genes, Viral
- Herpes Simplex
- Immediate-Early Proteins
- Introns
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- RNA, Viral
- Simplexvirus
- Transcription, Genetic
- Trigeminal Ganglion
- Ubiquitin-Protein Ligases