Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus.

doi:10.1016/j.diabet.2011.05.001

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Article

Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus.

Diabetes & metabolism - 1 Nov 2011

Cox A J, Wing M R, Carr J J, Hightower R C, Smith S C, Xu J, Wagenknecht L E, Bowden D W, Freedman B I

Abstract excerpt

AIM: Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in patients with obesity and type 2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene. This association remains to be investigated in African Americans with T2DM, a group at lower risk for hepatic steatosis relative to European Americans with T2DM. METHODS: We examined 422...

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Identifiers

PMID: 21665509
DOI: 10.1016/j.diabet.2011.05.001
PMCID: PMC3215942

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus.PMID 21665509Read ↗

Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.Semantic proximity Read ↗

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PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.Semantic proximity Read ↗

PNPLA3 rs 738409 and Other Nongenetic Factors Associated with Hepatic Steatosis Estimated by Magnetic Resonance Imaging Proton Density Fat Fraction in Adult Greek Subjects with Type 2 Diabetes Mellitus.Semantic proximity Read ↗

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.Semantic proximity Read ↗

PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: the NHLBI family heart study.Semantic proximity Read ↗

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Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype.Semantic proximity Read ↗

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