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Article

Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype.

Obesity (Silver Spring, Md.) - 1 Jun 2013

Petäjä Elina M, Sevastianova Ksenia, Hakkarainen Antti, Orho-Melander Marju, Lundbom Nina, Yki-Järvinen Hannele

Abstract excerpt

OBJECTIVE: Adipocyte hypertrophy has been suggested to be causally linked with inflammation and systemic insulin resistance. The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in hum...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 23913731
DOI: 10.1002/oby.20114

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23913731-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype.PMID 23913731Read ↗

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Semantic proximity Read ↗

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I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

<i><scp>PNPLA</scp>3</i> gene polymorphism accounts for fatty liver in community subjects without metabolic syndromeSemantic proximity Read ↗

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

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