Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes.

doi:10.1210/jc.2010-0814

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Article

Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes.

The Journal of clinical endocrinology and metabolism - 1 Dec 2010

Petit Jean-Michel, Guiu Boris, Masson David, Duvillard Laurence, Jooste Valerie, Buffier Perrine, Terriat Beatrice, Bouillet Benjamin, Brindisi Marie-Claude, Loffroy Romaric, Robin Isabelle, Hillon Patrick, Cercueil Jean-Pierre, Verges Bruno

Abstract excerpt

CONTEXT: Recently, it has been shown in the general population that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC), independently of visceral adiposity and insulin resistance. OBJECTIVE: In this study, we set out to determine whether LFC, evaluated using (1)H-MR spectroscopy, was associated with PNPLA3 rs738409 polymorphism in people with type 2 diabetes....

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Identifiers

PMID: 20826584
DOI: 10.1210/jc.2010-0814

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes.PMID 20826584Read ↗

PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.Semantic proximity Read ↗

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.Semantic proximity Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.Semantic proximity Read ↗

PNPLA3 rs 738409 and Other Nongenetic Factors Associated with Hepatic Steatosis Estimated by Magnetic Resonance Imaging Proton Density Fat Fraction in Adult Greek Subjects with Type 2 Diabetes Mellitus.Semantic proximity Read ↗

Correlations between PNPLA3 Gene Polymorphisms and NAFLD in Type 2 Diabetic Patients.Semantic proximity Read ↗

PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease.Semantic proximity Read ↗

Non-alcoholic fatty liver disease and subclinical atherosclerosis: A comparison of metabolically- versus genetically-driven excess fat hepatic storage.Semantic proximity Read ↗

Healthy PNPLA3 risk allele carriers present with unexpected body fat composition. A study of one thousand subjects.Semantic proximity Read ↗

Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content.Semantic proximity Read ↗

Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.Semantic proximity Read ↗

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.Semantic proximity Read ↗

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