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Article

Downregulation of Bcl-2 expression by miR-34a mediates palmitate-induced Min6 cells apoptosis.

Journal of diabetes research - 1 Jan 2014

Lin Xiaojie, Guan Hongyu, Huang Zhimin, Liu Juan, Li Hai, Wei Guohong, Cao Xiaopei, Li Yanbing

Abstract excerpt

Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β -cell treated with palmitate. Nevertheless, the underlying detailed mechanism is largely unknown. Here, we showed that miR-34a was significantly induced in Min6 pancreatic β -cell upon palmitate treatment. Elevated miR-34a promoted Min6 cell apoptosis. Intriguingly,...

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Identifiers

PMID: 24829923
DOI: 10.1155/2014/258695
PMCID: PMC4009326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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