Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.

doi:10.1073/pnas.88.16.7036

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Article

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991

Mortensen R M, Zubiaur M, Neer E J, Seidman J G

Abstract excerpt

The alpha i2 subunit of the inhibitory heterotrimeric guanine nucleotide-binding proteins is highly conserved in mammals and is expressed in all cell types, but its exact function is not yet defined. We have investigated the role of this protein by producing embryonic stem (ES) cells lacking a fu...

Topics

Adenylyl Cyclases
Alleles
Animals
Base Sequence
Blotting, Northern
Blotting, Southern
Cell Differentiation
Cell Line
DNA
Embryo, Mammalian
GTP-Binding Proteins
Genomic Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macromolecular Substances

Mice

Molecular Sequence Data

Oligonucleotide Probes

Polymerase Chain Reaction

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 1908087
DOI: 10.1073/pnas.88.16.7036
PMCID: PMC52228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1908087-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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