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GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos

9 Dec 2005

Abstract excerpt

The TGFbeta superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily, blocks classic BMP signaling in multiple contexts, interacts with BMP proteins and is expressed specifically in the node during gastrulation in a...

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PMID: 16339188
DOI: 10.1242/dev.02192

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