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Article

Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability.

Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007

Trachana Varvara, van Wely Karel H M, Guerrero Astrid Alonso, Fütterer Agnes, Martínez-A Carlos

Abstract excerpt

Numerical and/or structural centrosome abnormalities have been correlated with most solid tumors and hematological malignancies. Tumorigenesis also is linked to defects in the mitotic or spindle assembly checkpoint, a key control mechanism that ensures accurate segregation of chromosomes during m...

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Identifiers

PMID: 17299043
DOI: 10.1073/pnas.0611132104
PMCID: PMC1815243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17299043-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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