Article
APOE ε4 is associated with higher vitamin D levels in targeted replacement mice and humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2011
Huebbe Patricia, Nebel Almut, Siegert Sabine, Moehring Jennifer, Boesch-Saadatmandi Christine, Most Erika, Pallauf Josef, Egert Sarah, Müller Manfred James, Schreiber Stefan, Nöthlings Ute, Rimbach Gerald
Abstract excerpt
The allele ε4 of apolipoprotein E (APOE), which is a key regulator of lipid metabolism, represents a risk factor for cardiovascular diseases and Alzheimer's disease. Despite its adverse effects, the allele is common and shows a nonrandom global distribution that is thought to be the result of evolutionary adaptation. One hypothesis proposes that the APOE ε4 allele protects against vitamin D deficiency. Here we...
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