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Article

A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3.

Nature structural & molecular biology - 1 Sept 2008

Yu Eun Young, Wang Feng, Lei Ming, Lue Neal F

Abstract excerpt

Ever shorter telomeres 3 (Est3) is an essential telomerase regulatory subunit thought to be unique to budding yeasts. Here we use multiple sequence alignment and hidden Markov model-hidden Markov model (HMM-HMM) comparison to uncover potential similarities between Est3 and the mammalian telomeric protein Tpp1. Analysis of site-specific mutants of Candida albicans Est3 revealed functional distinctions between...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19172753
DOI: 10.1038/nsmb.1471
PMCID: PMC2656765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3.PMID 19172753Read ↗

Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.Semantic proximity Read ↗

Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.Semantic proximity Read ↗

The canonical RPA complex interacts with Est3 to regulate yeast telomerase activitySemantic proximity Read ↗

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase proteinSemantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation.Semantic proximity Read ↗

The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

Functional Conservation of the Telomerase Protein Est1p in HumansSemantic proximity Read ↗

Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo.Semantic proximity Read ↗

A bulged stem tethers Est1p to telomerase RNA in budding yeast.Semantic proximity Read ↗

A new telomerase RNA element that is critical for telomere elongation.Semantic proximity Read ↗

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