Article
Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines.
Journal of translational medicine - 9 Jun 2011
Lechner Melissa G, Megiel Carolina, Russell Sarah M, Bingham Brigid, Arger Nicholas, Woo Tammy, Epstein Alan L
Abstract excerpt
BACKGROUND: Tumor immune tolerance can derive from the recruitment of suppressor cell populations, including myeloid-derived suppressor cells (MDSC). In cancer patients, MDSC accumulation correlates with increased tumor burden, but the mechanisms of MDSC induction remain poorly understood. METHODS: This study examined the ability of human tumor cell lines to induce MDSC from healthy donor PBMC using in vitro...
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