Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.

doi:10.1002/mc.20806

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Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.

Molecular carcinogenesis - 1 Sept 2011

Yu Hongping, Huang Yu-jing, Liu Zhensheng, Wang Li-E, Li Guojun, Sturgis Erich M, Johnson David G, Wei Qingyi

Abstract excerpt

Both p53 tumor suppressor and murine double minute 2 (MDM2) oncoprotein are crucial in carcinogenesis. We hypothesized that MDM2 promoter single nucleotide polymorphisms (SNPs) SNP309 T > G, A2164G, and p53 codon 72 are associated with risk and age at onset of squamous cell carcinoma of head and neck (SCCHN). We genotyped these SNPs in a study of 1,083 Caucasian SCCHN cases and 1,090 cancer-free controls....

Topics

Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Base Sequence
Carcinoma, Squamous Cell
Case-Control Studies
Codon
DNA Primers
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Genetic Predisposition to Disease

Head and Neck Neoplasms

Humans

Male

Middle Aged

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 21656578
DOI: 10.1002/mc.20806
PMCID: PMC3142329

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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