MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients.

Abstract excerpt

Although mutations in p53 are rare in leukaemia, MDM2, the negative regulator of p53, is often overexpressed. Recently, a single nucleotide polymorphism (SNP) in the MDM2 promoter--within the oestrogen-receptor-binding region--resulting in either a G or T allele was shown to affect its transcription, with elevated MDM2 being produced when it is a G allele. Expectedly, SNP309G females were found to be at a higher...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age of Onset
• Share to Antineoplastic Agents